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Introduction to metabolomics
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Lipid quantification supports research on diabetic kidney disease
Annelie Falkevall and her co-workers showed that modulating the signalling pathway that controls lipid accumulation in the kidneys might be a possible strategy to treat diabetic kidney disease. Quantification of specific lipids by lipidomics analyses done at the Swedish Metabolomics Centre supported their studies.
See the article here:
Falkevall et al., Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease, Cell Metabolism, Volume 25, Issue 3, 7 March 2017, Pages 713-726, ISSN 1550-4131
Last Updated: 20 June 2017
An example where SMC have been providing results that could answer a research question!
Växtens kloroplaster är kända för en process som kallas fotosyntes, men i dessa organeller sker också många nedbrytningsreaktioner som krävs för olika cellulära funktioner, som exempelvis uppbyggnad av organellen och dess kvalitetskontroll.
I den nyligen publicerade artikeln i Nature Chemical Biology visar forskare från Stockholms universitet, i samarbete med forskare från bl a Karolinska Institutet, att peptider som genereras från pre-proteiner under mognad av kloroplaster bryts ner till aminosyror med hjälp av flerstegs peptidolytiska nätverk, en enzymologisk kaskad bestående av flera peptidnedbrytningsenzymer kallade oligopeptidaser och aminopeptidaser.
Last Updated: 10 November 2016
Do you need help developing an analytical method to answer your biological question?
Aiming to offer new quantitative methods at SMC, we welcome you to send us your targeted method development projects. We can provide pilot scale method development with the purpose of quantifying metabolites of interest for your biological question. Contact the Head of Facility, Jonas Gullberg, for more information or read the
found under "Method development".
Last Updated: 16 March 2016
Summary from Swedish Metabolomics Centre, 2013 - 2016 March
Since 2013, we have received more than 211 requests to SMC's service platform. Out of these requests, 150 projects were accepted and 76% have been completed. The accepted projects originated from 101 different researchers, covering 13 of the major institutes of higher education in Sweden. 12 projects were from international customers and 3 from commercial companies.
In the accepted service projects, we have run 14 500 samples from a variety of biological matrices and performed in total 25 000 analyses. We currently have 40 active Open Access users, and 43 000 analyzes have been performed in our Open Access service.
Distribution of accepted projects
Distribution of services provided by SMC
Last Updated: 30 May 2016
Agilent Qual Introduction Workshop - How to evaluate the quality of measurements
Welcome to a workshop for new users of Masshunter Qual. The workshop will cover basic functions in Qual, with a focus on evaluation of the quality of measurements in small to intermediate sample series, using internal standards and endogenous molecules.
Sign up for the workshop by sending an email to
no later than Monday the 25
When: Thursday the 28
of January, 09.00 - 15.00
Last Updated: 14 January 2016
SMC will become a SciLifeLab satellite facility
We are happy to announce that the Board of the Science for Life Laboratory (
) has decided that from year 2016 Swedish Metabolomics Centre will become a SciLifeLab satellite facility.
Last Updated: 04 November 2015
Waters Seminar about SFC and UPC2 in Umeå, May 19 2015
Waters is hosting a seminar where you can learn about Supercritical Fluid Chromatography developments, as well as learn about within which application areas it is having a significant impact.
Date: Tuesday May 19, 2015
Time: 9.00 - 11.00
Location: KBC, room KBF30
Last Updated: 13 May 2015
Advanced mass spectrometer to the Swedish Metabolomics Centre
Agilent Technologies, specialists in liquid chromatography and mass spectrometry, promote research at the Swedish Metabolomics Centre in Umeå. During a whole year researchers will be permitted to test run one of the company’s most advanced instruments.
At a seminar at the Chemical Biological Centre in Umeå on September 4
Peter Abrahamsson, Agilent’s product specialist for mass spectrometry in the Nordic countries, had good news: From October Swedish research will have access to their latest technology in mass spectrometry, an Ion Mobility Q-TOF, which will make it possible to conduct metabolite research which currently is difficult to perform anywhere else in Europe.
Watch the video of the announcemen
Last Updated: 07 May 2015
Swedish Metabolomics Centre education day in Umeå, 7th of May 2015
Welcome to an education session that will focus on the workflow at the Swedish Metabolomics Centre, and the tools/basic software used for the data handling. If you cannot attend in person, there is the possibility to follow the education via video link.
to attend the seminar or follow the education via link.
: Hörsal N 460
: Johan Bures väg 14-16, Umeå universitet
: Naturvetarhuset (
(possibility to follow the education via video link)
8.30 - 8.40
8.40 - 9.30
Metabolomics workflow – Generating reliable data
9.30 - 10.00
10.00 - 10.40
Quality assurance, target and un-target processing strategies using ProFinder
10.45 - 11.30
Analyzing large scale metabolomics studies - Data Processing
11.30 - 12.00
Questions and discussion
Download the agenda as pdf
Last Updated: 07 May 2015
We are updating our webpage
We are updating our webpage. If you encounter any problems or have comments, do not hesitate to
Last Updated: 07 May 2015
Head of Facility