Annelie Falkevall and her co-workers showed that modulating the signalling pathway that controls lipid accumulation in the kidneys might be a possible strategy to treat diabetic kidney disease. Quantification of specific lipids by lipidomics analyses done at the Swedish Metabolomics Centre supported their studies.   
Graphical abstract high quality 1 s2.0 S1550413117300396 fx1
See the article here:

Falkevall et al., Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease, Cell Metabolism, Volume 25, Issue 3, 7 March 2017, Pages 713-726, ISSN 1550-4131
https://doi.org/10.1016/j.cmet.2017.01.004
peptidnedbrytningskaskad
Växtens kloroplaster är kända för en process som kallas fotosyntes, men i dessa organeller sker också många nedbrytningsreaktioner som krävs för olika cellulära funktioner, som exempelvis uppbyggnad av organellen och dess kvalitetskontroll.

I den nyligen publicerade artikeln i Nature Chemical Biology visar forskare från Stockholms universitet, i samarbete med forskare från bl a Karolinska Institutet, att peptider som genereras från pre-proteiner under mognad av kloroplaster bryts ner till aminosyror med hjälp av flerstegs peptidolytiska nätverk, en enzymologisk kaskad bestående av flera peptidnedbrytningsenzymer kallade oligopeptidaser och aminopeptidaser.

Read more
Aiming to offer new quantitative methods at SMC, we welcome you to send us your targeted method development projects. We can provide pilot scale method development with the purpose of quantifying metabolites of interest for your biological question. Contact the Head of Facility, Jonas Gullberg, for more information or read the article found under "Method development".
Since 2013, we have received more than 211 requests to SMC's service platform. Out of these requests, 150 projects were accepted and 76% have been completed. The accepted projects originated from 101 different researchers, covering 13 of the major institutes of higher education in Sweden. 12 projects were from international customers and 3 from commercial companies.

In the accepted service projects, we have run 14 500 samples from a variety of biological matrices and performed in total 25 000 analyses. We currently have 40 active Open Access users, and 43 000 analyzes have been performed in our Open Access service. 


 Distribution of accepted projects
DiagramCustomers
Distribution of services provided by SMC
DiagramServices 
Welcome to a workshop for new users of Masshunter Qual. The workshop will cover basic functions in Qual, with a focus on evaluation of the quality of measurements in small to intermediate sample series, using internal standards and endogenous molecules.

Sign up for the workshop by sending an email to This email address is being protected from spambots. You need JavaScript enabled to view it. no later than Monday the 25th of January.

When: Thursday the 28th of January, 09.00 - 15.00
Where: N260
We are happy to announce that the Board of the Science for Life Laboratory (SciLifeLab) has decided that from year 2016 Swedish Metabolomics Centre will become a SciLifeLab satellite facility.
Waters is hosting a seminar where you can learn about Supercritical Fluid Chromatography developments, as well as learn about within which application areas it is having a significant impact.

Date: Tuesday May 19, 2015
Time: 9.00 - 11.00
Location: KBC, room KBF30

Read more here.
Agilent Technologies, specialists in liquid chromatography and mass spectrometry, promote research at the Swedish Metabolomics Centre in Umeå. During a whole year researchers will be permitted to test run one of the company’s most advanced instruments.

At a seminar at the Chemical Biological Centre in Umeå on September 4th Peter Abrahamsson, Agilent’s product specialist for mass spectrometry in the Nordic countries, had good news: From October Swedish research will have access to their latest technology in mass spectrometry, an Ion Mobility Q-TOF, which will make it possible to conduct metabolite research which currently is difficult to perform anywhere else in Europe.

Watch the video of the announcemen here.
Welcome to an education session that will focus on the workflow at the Swedish Metabolomics Centre, and the tools/basic software used for the data handling. If you cannot attend in person, there is the possibility to follow the education via video link.

Registration via
http://kbc-forms.upsc.se/forms/27-smc-education-days.html
to attend the seminar or follow the education via link.

Room: Hörsal N 460
Adress: Johan Bures väg 14-16, Umeå universitet
House: Naturvetarhuset (map)

Thursday 7th May 2015 (possibility to follow the education via video link)
AGENDA

8.30 - 8.40
Introduction

8.40 - 9.30
Metabolomics workflow – Generating reliable data

9.30 - 10.00
Coffee

10.00 - 10.40
Quality assurance, target and un-target processing strategies using ProFinder

10.45 - 11.30
Analyzing large scale metabolomics studies - Data Processing

11.30 - 12.00
Questions and discussion

Download the agenda as pdf here.
We are updating our webpage. If you encounter any problems or have comments, do not hesitate to This email address is being protected from spambots. You need JavaScript enabled to view it..

Contact

Jonas Gullberg
Head of Facility
This email address is being protected from spambots. You need JavaScript enabled to view it.